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Home / Animal Model / Disease Mice

H11-CAG-LSL-Myc

SKU : BHAM00125

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KI-00039
Description	Model Description: The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase. Official Symbol: Igs2 MGI ID: 5461148 Pubmed: Igs2
Nomenclature	C57BL/6JSmoc-Igs2^{em1(CAG-LSL-Myc)Smoc}
Application	Tumor-Bearing Model,Cancer Research
KI/KO Gene	Igs2
Synonyms	H11,Hipp11,Iis2

Reference	MGI:6196129

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