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KPC

SKU : BHAM00156

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-KI-210096
Description	Model Description: The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H (NM-KI-18028),Kras-LSL-G12D (NM-KI-190003)were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue. Official Symbol: Trp53 NCBI ID: 22059 MGI ID: 98834 Ensembl ID: ENSMUSG00000059552 Pubmed: Trp53 Human Ortholog: TRP53
Nomenclature	C57BL/6JSmoc-Trp53^em4(R172H)Kras^{em4(LSL-G12D)}Tg(Pdx1-cre)Smoc
Application	Spontaneous Pancreatic Tumor
Disease	Pancreatic Carcinoma
KI/KO Gene	Trp53
Synonyms	bbl; bfy; bhy; p44; p53; Tp53

Reference	Pancreatology . 2020 Jan;20(1):79-88. doi: 10.1016/j.pan.2019.11.006. Epub 2019 Nov 18.

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