JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / VECTOR &VIRUS / Lentivirus

Trop2 Lentivirus (Macaca fascicularis/Cynomolgus)

SKU : BHV18200015

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

BPS Bioscience

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Description
Review(s)

Mfr.No.	78776
Description	The Trop2 (Trophoblast cell-surface antigen 2) Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with Macaca fascicularis (also known as crab-eating macaque or cynomolgus monkey) Trop2 (XP_005543292.2) driven by an EF1A promoter. The lentiviruses also transduce a puromycin selection gene. Trophoblast cell-surface antigen 2 (Trop-2, also known as tumor-associated calcium signal transducer 2, TACSTD2, GA733-1 or M1S1), is a cell surface glycoprotein involved in stem-cell like functions. It is overexpressed in a variety of solid cancers compared to normal cells, and links with patient prognosis. Through a variety of signaling pathways, Trop-2 regulates cancer growth and metastasis. The use of antibodies, antibody-fusion proteins, small molecule inhibitors and other strategies directed at Trop-2 has resulted in promising results. Its use as biomarker and target in cancer therapy shows its importance in the field. The lentivirus particles were produced in HEK293T cells in medium containing 90% DMEM + 10% FBS. Virus particles can be packaged in custom formulations by special request, for an additional fee. Biosafety The lentiviruses are produced with a SIN (self-inactivation) lentivector which ensures self-inactivation of the lentiviral construct after transduction and after integration into the genomic DNA of the target cells. None of the HIV genes (gag, pol, rev) will be expressed in the transduced cells, as they are expressed from packaging plasmids lacking the packing signal and are not present in the lentivirus particle. Although the pseudotyped lentiviruses are replication-incompetent, they require the use of a Biosafety Level 2 facility. BPS Bioscience recommends following all local federal, state, and institutional regulations and using all appropriate safety precautions.
Synonyms	Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1, TACSTD2, GA733-1, M1S1, TROP2
Applications Range	Expression of Trop-2 in cells of interest. Generate stable cell lines expressing cynomolgus Trop2 (puromycin resistant).
Storage	Lentiviruses are shipped with dry ice. For long-term storage, it is recommended to store the lentiviruses at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. Titers can drop significantly with each freeze/thaw cycle.
Shipping	-80°C

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHV18200015	78776	500 µl x 2	$850		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.