Mammalian homologs of the Drosophila Mad gene include Smad1 (also designated Madr1 or JV4-1), Smad2 (also designated Madr2 or JV18-1), Smad3, Smad4 (also designated DPC4), Smad5, Smad6, Smad7 and Smad8 (also designated Smad9). Smad1 and Smad5 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGFb and activin-mediated growth modulation. Smad4 is required for all of the above activities and necessitates FAST-1 for DNA binding. Smad6 and Smad7 regulate the response to activin/ TGFb signaling by interfering with TGFb-mediated phosphorylation of other Smad family members.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
SMAD3
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of SMAD, mothers against DPP homolog 3 (Drosophila) Adenovirus (Ad-SMAD3)