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Home / VECTOR &VIRUS / Adenovirus

Neuroblastoma RAS viral (v-ras) oncogene homolog Adenovirus (Ad-N-ras)

SKU : BHV21600260

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Description
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Mfr.No.	1565
Description	H-, K- and N-Ras genes encode 21 kDa guanine nucleotide-binding proteins. H-Ras and K-Ras were first identified as oncogenes of acutely transforming RNA tumor viruses. Subsequently, mutated Ras genes have been found in many human tumors, providing evidence for a common genetic target in cancer. Ras-encoded proteins bind to GDP and to GTP with high affinity and possess a low level of intrinsic GTPase activity that can be stimulated over 100-fold by interaction with cytosolic GTPase activating protein (GAP). M-Ras was identified as a GTPase that shares structural similarities to the Ras family proteins. In mammals, a variety of extracellular growth factors that act through protein tyrosine kinase receptors, such as insulin, platelet-derived growth factor and nerve growth factor, require Ras to exert their effects. Ras p21 in its active GTP bound state binds to Raf-1, resulting in activation of the MAP kinase signaling cascade. An additional member of the Ras family, Rheb (Ras-related GTP-binding protein), also interacts with Raf-1. This interaction is potentiated by growth factors and agents that increase cAMP levels. R-Ras and TC 21 (also designated R-Ras-2) are also members of the Ras family.
Categories	Adenovirus, Over-Expression
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Gene expression
Promoter	CMV (ubiquitous)
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3)
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	N-ras
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600260	1565	200 µL	$690		Add to Cart

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