A distant member of the MAP kinase family, designated c-Jun N-terminal kinase (JNK1), is activated by dual phosphorylation at a Thr-Pro-Tyr motif (as compared to the Thr-Glu-Tyr phosphorylation motif characteristic of MAP kinases) during response to ultraviolet (UV) light. JNK1 functions to phosphorylate c-Jun at N-terminal serine regulatory sites, Ser-63 and Ser-73, mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. Two additional members of the JNK family, JNK2 (also designated p54(alpha), MAPK9) and JNK3 (also designated p54(beta)), were described in a study in which an independent isolate of JNK1 was designated p54(gamma). These proteins are designated stress-activated protein kinases, or SAPKs. This is JNK2 alpha-2 isoform.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
JNK2
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Mitogen-activated protein kinase 9 Adenovirus (Ad-JNK2)