Several protein tyrosine kinases have been identified within the Src gene family. On the basis of their associations with specific cell surface receptors, Src gene family members play critical roles in various signal transduction pathways. The highest levels of expression of the prototype member of this gene family, Src p60, are observed in platelets and in neuronal tissues. In contrast to Lck, which is expressed in T lymphocytes and natural killer cells, Lyn is expressed at highest levels in macrophages, platelets and B lymphocytes. Fyn is expressed in two different forms due to mutually exclusive splicing of alternative seventh exons. One form is expressed in the brain and the other in T lymphocytes. Yes p62 is broadly expressed in a wide range of cell types while c-Fgr p55 is preferentially expressed in cells of hematopoietic origin of the myeloid lineage. The Hck gene is expressed predominantly in cells of myeloid and B lymphocyte lineages. Blk is expressed in B lymphocytes, and Rak (also designated Frk in human, Gtk in rat and Bsk in mouse) is expressed in tissues of lymphoid, brain, breast, colon and bladder origin.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
LCK
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Lymphocyte-specific protein tyrosine kinase Adenovirus (Ad-LCK)