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Home / VECTOR &VIRUS / Lentivirus

ERG Reporter Lentivirus

SKU : BHV19400090

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Mfr.No.	LTV-0099, LTV-0099-1S, LTV-0099-2S, LTV-0099-3S, LTV-0099-4S, LTV-0099-5S, LTV-0099-6S, LTV-0099-15S, LTV-0099-16S
Description	ERG Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse Ets related gene (ERG) transcriptional activity in mammalian cells. The ERG reporter is constructed with consensus ERG DNA-binding elements to read out ERG transcriptional activity in mammalian cells. As a member of the erythroblast transformation-specific (ETS) family of transcriptional factors, ERG is a key regulator of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. All members of the Ets family have a core DNA-binding motif of GGAA but each member has a preference for different flanking sequences. ERG can synergize with AP1 for optimal transcriptional activity and, therefore, the ERG reporter includes an AP-1-like motif. Chromosomal translocations of ERG result in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing s sarcoma, and FUS-ERG in acute myeloid leukemia. The ERG reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation and is ideal for studying ERG transcriptional activity in difficult-to-transfect cells including primary and/or thawed cells.
Serotype	VSV-G
Reporter	Firefly Luc, RFP, BFP2, GFP
Response Element	ERG response element (consensus ERG DNA binding elements)
Selection	Blasticidin, Puromycin
Signaling pathway	ERG Signaling Pathway
Species	Human/mouse
Applications Range	Monitor ERG transcriptional activity in mammalian cells, screen for activators or inhibitors of ERG transcriptional activity. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Your price	Quantity
BHV19400090-1	LTV-0099-1S	5x10^6	Puromycin	GFP	$595		Add to Cart
BHV19400090-2	LTV-0099-2S	5x10^6	Blasticidin	RFP	$595		Add to Cart
BHV19400090-3	LTV-0099-3S	2x10^6	Puromycin	Firefly Luc	$595		Add to Cart
BHV19400090-4	LTV-0099-4S	2x10^6	Blasticidin	Firefly Luc	$595		Add to Cart
BHV19400090-5	LTV-0099-5S	5x10^6	Blasticidin	GFP	$595		Add to Cart
BHV19400090-6	LTV-0099-6S	5x10^6	Puromycin	RFP	$595		Add to Cart
BHV19400090-7	LTV-0099-15S	5x10^6	Puromycin	BFP2	$595		Add to Cart
BHV19400090-8	LTV-0099-16S	5x10^6	Blasticidin	BFP2	$595		Add to Cart

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