Cre and RFP expressing RGD fiber modified Adenovirus (Ad(RGD)-RFP-iCre)

Mfr.No.	1770
Description	Since the cell entry of adenovirus is dependent on the initial recognition of the coxsackie-adenovirus receptor (CAR) on the surafce, the infection efficiency of adenovirus is very low for cells with low or no CAR receptor. An Arg-Gly-Asp (RGD) motif was introduced in the surface-exposed loop of the adenovirus fiber knob, this enables the adenovirus to bypass CAR and mediate cell entry via RGD binding integrins.RDG modified adenovirus can be used for "retargeting" cells that regular adenovirus doesn't work well. The infection effeciency of RDG modified adenovirus can be tens or hundreds of times higher than standard Ad5 in some cells, including human or mouse macrophages and T cells etc.This is a RGD modified replication-deficient adenovirus expressing codon optimized Cre and RFP under a CMV promoter. The Cre and RFP are separated by a 2A peptide.
Categories	Adenovirus, Over-Expression, Fiber-modified Ad5
Product Type	Pre-Made
Virus Type	Adenovirus
Function	Reporter/Tag
Promoter	CMV (ubiquitous)
Reporter	RFP
Storage Buffer	DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone	Human Adenovirus Type5 (dE1/E3) with RGD-fiber modification
Shelf Life	12 Months
HS Code	3822190000
UNSPSC Code	41106621
Insert Gene	RFP-iCre
Serotype	RGD
Availability	Ready to Ship
Titer	1x10^10 PFU/ml
Reporter	RFP
Storage	-80C
Shipping	Dry Ice

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SKU	Supplier No.	Size	Your price	Quantity
BHV21600338	1770	200 µL	$495		Add to Cart