The mammalian homologs of the Ced-4 proteins, Apaf-1 (Ced-4), Nod1 (CARD4) and Nod2 contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker's A box (P-loop) and B box (Mg2+-binding site). Nod1 contains a putative regulatory domain and multiple leucine-rich repeats. Nod1 is a member of a growing family of intracellular proteins that share structural homology to the apoptosis regulator Apaf-1. Nod2 comprises two N-terminal CARDs, a nucleotide-binding domain, and multiple C-terminal leucine-rich repeats. Mutations in Nod2 confer susceptibility to Crohn disease, a chronic inflammatory bowel disorder.
Categories
Adenovirus, Over-Expression
Product Type
Pre-Made
Virus Type
Adenovirus
Function
Gene expression
Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Shelf Life
12 Months
HS Code
3822190000
UNSPSC Code
41106621
Insert Gene
NOD1
Availability
Ready to Ship
Titer
1x10^10 PFU/ml
Storage
-80C
Shipping
Dry Ice
Reviews of Caspase recruitment domain family, member 4 Adenovirus (Ad-NOD1)