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Home / VECTOR &VIRUS / Lentivirus

AARE Reporter Lentivirus

SKU : BHV19400033

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Mfr.No.	LTV-0037, LTV-0037-1S, LTV-0037-2S, LTV-0037-3S, LTV-0037-4S, LTV-0037-5S, LTV-0037-6S, LTV-0037-4SIC
Description	Fluorescent AARE Reporter Lentivirus: High-quality, amino acid response element (AARE) lentiviral reporter system that provides a sensitive fluorescent readout to AARE/ATF4 activity (amino acid response pathway, eIF2alpha/ATF4 pathway) in human/mouse cells. This product uses tandem repeats of AARE from the human asparagine synthase promoter, which contain the nutrient-sensing response elements (NSRE-1 and NSRE-2), to drive the reporter expression in mammalian cells in response to amino acid or glucose deprivation. Transient (short-term) amino acid limitation activates GCN2 kinase, which phosphorylates eIF2a, resulting in ATF4 activation. Prolonged amino acid or glucose deprivation also makes the AARE respond to ER stress pathway activation. The transcription factor (TF) reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying amino acid response pathway activity/cellular response to metabolic stress in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	EF1a
Serotype	VSV-G
Reporter	Firefly Luc, RFP, Renilla Luc, GFP
Response Element	Amino acid response element (AARE)
Selection	Blasticidin, Puromycin
Signaling pathway	Amino acid response pathway (eIF2alpha/ATF4 pathway)
Species	Human/mouse
Applications Range	Monitor eIF2alpha/ATF4 pathway and amino acid/metabolic stress response in mammalian cells, screen for activators or inhibitors of the eIF2alpha/ATF4 pathway and amino acid/metabolic stress response. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400033-1	LTV-0037-1S	5x10^6	Puromycin	GFP	EF1a	$595		Add to Cart
BHV19400033-2	LTV-0037-2S	5x10^6	Blasticidin	RFP	EF1a	$595		Add to Cart
BHV19400033-3	LTV-0037-3S	2x10^6	Puromycin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400033-4	LTV-0037-4S	2x10^6	Blasticidin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400033-5	LTV-0037-5S	5x10^6	Blasticidin	GFP	EF1a	$595		Add to Cart
BHV19400033-6	LTV-0037-6S	5x10^6	Puromycin	RFP	EF1a	$595		Add to Cart
BHV19400033-7	LTV-0037-4SIC	2x10^6	Blasticidin	Renilla Luc	EF1a	$595		Add to Cart

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