N-terminal 10xHis-tagged and C-terminal Twin-Strep-tagged
Molecular Weight
27.3 kDa
Relevance
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.<br />(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Source
Mammalian cell
Form
Liquid
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Purity
Greater than 95% as determined by SDS-PAGE.
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. <br />Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Reference
Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.<br />Zheng A., Yuan F., Li Y., Zhu F., Hou P., Li J., Song X., Ding M., Deng H.<br />J. Virol. 81:12465-12471 (2007)