Crystallography-Grade Recombinant Proteins

High Purity . High Activity .  High Consistency .  High Stability

Aurora Biolabs' Recombinant Proteins Are Known For:

• Batch-to-Batch Consistency – Ensuring reliable and reproducible results for every experiment.
• Stringent Quality Control Tests – Comprehensive QC processes to guarantee high standards in every product.
• Exceptional Protein Purity – Available in purity levels of >95%, >98%, and >99% to suit various research needs.
• High Bioactivity – Bioactivity assays demonstrate an ED50 of 0.1-1.0 ng/mL, ensuring optimal performance.
• Low Endotoxin Levels – Minimal endotoxin content, maintained at <1 EU or <0.1 ng/mL (LAL method), ideal for sensitive applications.
• Mycoplasma Free – Guaranteed mycoplasma-free proteins, ensuring contamination-free research environments.

Aurora Biolabs' Extensive Catalog of Recombinant Proteins

1. Drug Target Proteins
Our catalog includes a comprehensive range of drug target proteins, such as:

• KRAS WT and mutant variants (G12C, G12D, G12R, G12V, G13D) with GDP or GppNHp loaded
• SOS1, cRAF, CDKs, PKM2, EIF4E, MNK2, Bcl2, DNA Polymerase Theta (POLQ)
• PKMYT1 and many more

2. Cytokines & Growth Factors
We offer high-purity recombinant cytokines and growth factors, including:

• bFGF, aFGF, VEGF, and additional growth factors

3. LIF, SHH, and ME Proteins
Our catalog also features key developmental and metabolic proteins, such as:

• Human Leukemia Inhibitory Factor (LIF), Mouse LIF, Human Sonic Hedgehog (SHH)
• Malic enzyme proteins (ME1, ME2, ME3) and more

4. Tag Removal Proteases
To support downstream applications, we provide:

• TEV Protease, SUMO Protease (Ulp1), PreScission Protease (HRV 3C), and YopH

5. SARS-CoV-2 Proteins
For COVID-19 research, we offer recombinant SARS-CoV-2 proteins, including:

• Mpro/3CL, PLpro/NSP3, Helicase/NSP13, NSP7, and NSP8

With such an extensive range of high-quality recombinant proteins, Aurora Biolabs continues to be a trusted resource for research in drug discovery, developmental biology, and infectious diseases.

Aurora Biolabs' High-Throughput TR-FRET Assay Kits

Convenient . Time-Saving . Sensitive . Accurate

Most of Aurora Biolabs' assay kits are designed using High-Throughput Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) technology. These advanced assays offer numerous advantages:

• Convenience – Simplified workflow with minimal hands-on time.
• Speed – Rapid readouts, enabling high-throughput screening.
• Sensitivity – Capable of detecting low concentrations of analytes with precision.
• High Quantitative Accuracy – Delivers reliable, reproducible results for critical applications.

TR-FRET assays are widely employed in drug target-inhibitor screening, making Aurora Biolabs' kits an ideal choice for researchers in drug discovery and pharmacology.

Aurora Biolabs' Catalog of Assay Kits

• KRAS (WT/G12C/G12D/G12V/G12R) Nucleotide Exchange Assay Kit
  Available in 400 and 4000 reaction formats, ideal for high-throughput screening of KRAS inhibitors.
• KRAS (WT/G12C/G12D/G12V/G12R) cRAF Binding Assay Kit
  Offered in 400 and 4000 reaction formats, optimized for studying KRAS-cRAF interactions in drug discovery.

• DNA Polymerase Theta Activity Assay Kit
  Suitable for 96 and 384 reaction formats, supporting research in DNA repair and polymerase function.

• CDK2/CyclinA2 Assay Kit – Designed for the study of cyclin-dependent kinase activity in cell cycle regulation.
• WEE1/PKMYT1 Binding Assay Kit – Essential for screening inhibitors targeting the WEE1-PKMYT1 pathway.

• eIF4E/eIF4G Binding Assay Kit – A key tool for analyzing translation initiation complex formation.

• SARS-CoV-2 Mpro/PLpro Assay Kit – Developed for screening inhibitors of key SARS-CoV-2 proteases, supporting antiviral drug development.

Proven Compound Screening Services with a Library of 150,000+ Compounds

Comprehensive Assay Services & Customization by Aurora Biolabs

Aurora Biolabs offers a wide range of biochemical and cell-based assays, tailored for drug discovery and research applications. Their expertise spans several advanced assay types:

• KRAS Assays – Specialized assays for wild-type and mutant KRAS, supporting inhibitor screening and drug discovery.
• Kinase Assays – High-throughput assays for studying kinase activity and screening kinase inhibitors.
• TR-FRET Assays – Time-Resolved Fluorescence Resonance Energy Transfer assays, known for high sensitivity and quantitative accuracy.
• ADP-Glo Assays – Luminescent kinase assays for measuring ADP production in real-time.
• Custom Assays – Bespoke assay development tailored to unique project needs.
• Fluorescence Polarization Assays – Ideal for studying molecular interactions with high precision.
• SPR Binding Assays – Surface Plasmon Resonance assays for real-time binding affinity measurements.

The Role of Crystallography-Grade Proteins in Advancing Structure-Based Drug Discovery

Advancing Drug Discovery: Co-Crystallization of Inhibitor Compounds

SARS-CoV-2 Mpro Assay Kit: A Key Tool for Evaluating Inhibitors and Understanding Mutations