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Home / Shanghai Model Organisms Center, Inc. / Animal Model / Humanized Knockins
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Humanized Knockins

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Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

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  • hCDH3

    hCDH3

    hCDH3

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Cd
    • Strain : Developing
    • KI/KO Gene : Cdh3
    • Synonyms : Cadp, Cdhp, Pca
  • hCDH17

    hCDH17

    hCDH17

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Cd
    • Strain : Developing
    • KI/KO Gene : Cdh17
    • Synonyms : HPT-1, HPT-1/LI
  • hFCGR2B/h4-1BB(2)

    hFCGR2B/h4-1BB(2)

    hFCGR2B/h4-1BB(2)

    • Description : hFCGR2B(NM-HU-2
    • Nomenclature : C57BL/6Smoc-Fcg
    • Strain : Embryo cryopres
    • KI/KO Gene : Fcgr2b
    • Synonyms : AI528646; CD32
  • hGDF15

    hGDF15

    hGDF15

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Gdf
    • Strain : Repository Live
    • KI/KO Gene : Faah
    • Synonyms : AW412498
  • hHER3

    hHER3

    hHER3

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Erb
    • Strain : Repository Live
    • KI/KO Gene : Erbb3
    • Synonyms : Her3; C76256; E
  • hHER2

    hHER2

    hHER2

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Erb
    • Strain : Repository Live
    • KI/KO Gene : Erbb2
    • Synonyms : Neu; HER2; HER-
  • hHBB

    hHBB

    hHBB

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Hbb
    • Strain : Repository Live
    • KI/KO Gene : Hbb-bt
    • Synonyms : Beta-t
  • hICOS(2)

    hICOS(2)

    hICOS(2)

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Ico
    • Strain : Embryo cryopres
    • KI/KO Gene : Icos
    • Synonyms : AILIM CCLP CRP-
  • hIGHG4

    hIGHG4

    hIGHG4

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Igh
    • Strain : Repository Live
    • KI/KO Gene : Ighg1
    • Synonyms : IgG1 Igh-4
  • hIFNGR1/hIFNGR2

    hIFNGR1/hIFNGR2

    hIFNGR1/hIFNGR2

    • Description : hIFNGR1(NM-HU-1
    • Nomenclature : C57BL/6Smoc-Ifn
    • Strain : Embryo cryopres
    • KI/KO Gene : IFNGR1
    • Synonyms : Ifgr; CD119; If
  • hIL13

    hIL13

    hIL13

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Embryo cryopres
    • KI/KO Gene : IL13
    • Synonyms : IL-13; P600
  • hIL12RB2

    hIL12RB2

    hIL12RB2

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Repository Live
    • KI/KO Gene : Ccr4
    • Synonyms : LESTR; Sdf1r; C
  • hIL12A/hIL12B/hIL12RB1/hIL12RB2

    hIL12A/hIL12B/hIL12RB1/hIL12RB2

    hIL12A/hIL12B/hIL12RB1/hIL12RB2

    • Description : hIL12A(NM-HU-20
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Developing
    • KI/KO Gene : Il12b
    • Synonyms : p40, Il-12b, Il
  • hIL11

    hIL11

    hIL11

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Embryo cryopres
    • KI/KO Gene : Il11
    • Synonyms : IL-11
  • hIL18

    hIL18

    hIL18

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Sperm cryoprese
    • KI/KO Gene : Il18
    • Synonyms : Igif; Il-18
  • hIL17A

    hIL17A

    hIL17A

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Embryo cryopres
    • KI/KO Gene : IL17A
    • Synonyms : Il17; Ctla8; IL
  • hIL1B(BALB/c)

    hIL1B(BALB/c)

    hIL1B(BALB/c)

    • Description : The endogenous
    • Nomenclature : BALB/cAnSmoc-Il
    • Strain : Repository Live
    • KI/KO Gene : IL1B
    • Synonyms : Il-1b; IL-1bet
  • hIL1B

    hIL1B

    hIL1B

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Il1
    • Strain : Repository Live
    • KI/KO Gene : Il1b
    • Synonyms : Il-1b, IL-1beta
  • hTHPO

    hTHPO

    hTHPO

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Thp
    • Strain : Embryo cryopres
    • KI/KO Gene : Thpo
    • Synonyms : Ml, Tpo, Mgdf,
  • hTLR9/hOX40

    hTLR9/hOX40

    hTLR9/hOX40

    • Description : This TLR9 and O
    • Nomenclature : C57BL/6Smoc-Tlr
    • Strain : Embryo cryopres
    • KI/KO Gene : Tnfrsf4
    • Synonyms : Ox40; ACT35;
  • hTLR9

    hTLR9

    hTLR9

    • Description : This TLR9 human
    • Nomenclature : C57BL/6Smoc-Tlr
    • Strain : Embryo cryopres
    • KI/KO Gene : Tlr9
    • Synonyms : Ox40; ACT35;
  • hTLR8/Lyz2-DTREGFP

    hTLR8/Lyz2-DTREGFP

    hTLR8/Lyz2-DTREGFP

    • Description : NM-KI-190041 wa
    • Nomenclature : C57BL/6Smoc-Lyz
    • Strain : Embryo cryopres
    • KI/KO Gene : TLR8
    • Synonyms : Ox40; ACT35;
  • hTLR4

    hTLR4

    hTLR4

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Tlr
    • Strain : Embryo cryopres
    • KI/KO Gene : Tlr4
    • Synonyms : Lps; Ly87; Ran/
  • hTIGIT/hTNFR2

    hTIGIT/hTNFR2

    hTIGIT/hTNFR2

    • Description : hTIGIT(3)(NM-HU
    • Nomenclature : C57BL/6Smoc-Tig
    • Strain : Repository Live
    • KI/KO Gene : CTLA4
    • Synonyms : Cd152; Ly-56;
  • hTNFR2/hPD-1

    hTNFR2/hPD-1

    hTNFR2/hPD-1

    • Description : hTNFRSF1B(NM-HU
    • Nomenclature : C57BL/6Smoc-Tnf
    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
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