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Humanized Knockins

Shanghai Model Organisms Center, Inc.

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hPD-1/hCTLA-4(BALB/c)

    hPD-1/hCTLA-4(BALB/c)

    • Description : hPD-1(NM-HU-190
    • Nomenclature : BALB/cAnSmoc-Pd
    • Strain : Embryo cryopres
    • KI/KO Gene : CTLA4
    • Synonyms : Cd152; Ly-56;
  • hPD-1/hCD27(2)

    hPD-1/hCD27(2)

    • Description : hPD-1(NM-HU-000
    • Nomenclature : C57BL/6Smoc-Pdc
    • Strain : Embryo cryopres
    • KI/KO Gene : CD27
    • Synonyms : Cd27; S152; T
  • hPD-1

    hPD-1

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Pdc
    • Strain : Repository Live
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
  • hPD-1/hPD-L1/hCD73(2)

    hPD-1/hPD-L1/hCD73(2)

    • Description : hPD-1(NM-HU-000
    • Nomenclature : C57BL/6Smoc-Pdc
    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
  • hEGFR

    hEGFR

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Egf
    • Strain : Developing
    • KI/KO Gene : Egfr
    • Synonyms : Wa5; wa2; Erbb;
  • hDMPK

    hDMPK

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Dmp
    • Strain : Repository Live
    • KI/KO Gene : Dmpk
    • Synonyms : DM; DMK; Dm15;
  • hGIPR

    hGIPR

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Gip
    • Strain : Repository Live
    • KI/KO Gene : Gipr
    • Synonyms : GIP-R,Gm160,Gm1
  • hHGF

    hHGF

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Hgf
    • Strain : Embryo cryopres
    • KI/KO Gene : Hgf
    • Synonyms : SF, NK1, NK2, H
  • hGNRHR

    hGNRHR

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Gnr
    • Strain : Sperm cryoprese
    • KI/KO Gene : Gnrhr
    • Synonyms : SF, NK1, NK2, H
  • hIGHG1

    hIGHG1

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Igh
    • Strain : Repository Live
    • KI/KO Gene : Ighg1
    • Synonyms : IgG1 Igh-4
  • hIL17RA(BALB/c)

    hIL17RA(BALB/c)

    • Description : The endogenous
    • Nomenclature : BALB/cAnSmoc-Il
    • Strain : Repository Live
    • KI/KO Gene : IL17RA
    • Synonyms : Il17r; Cdw217
  • hPD-1/hSIGLEC15

    hPD-1/hSIGLEC15

    • Description : hPD-1(NM-HU-000
    • Nomenclature : C57BL/6Smoc-Pdc
    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
  • hPD-1/hPD-L1/hPD-L2

    hPD-1/hPD-L1/hPD-L2

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Pdc
    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
  • hPD-L1(2)/hCCR8

    hPD-L1(2)/hCCR8

    • Description : hPD-1(2)(NM-HU-
    • Nomenclature : C57BL/6Smoc-Cd2
    • Strain : Embryo cryopres
    • KI/KO Gene : Cd274
    • Synonyms : B7h1; Pdl1; P
  • hPD-1/hVISTA

    hPD-1/hVISTA

    • Description : hPD-1(NM-HU-000
    • Nomenclature : C57BL/6Smoc-Vis
    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
  • hPD-1/hTLR9

    hPD-1/hTLR9

    • Description : hPD-1(NM-HU-000
    • Nomenclature : C57BL/6Smoc-Pdc
    • Strain : Embryo cryopres
    • KI/KO Gene : Pdcd1
    • Synonyms : PD-1; Pdc1; Ly1
  • hPD-L1/hSEMA4D

    hPD-L1/hSEMA4D

    • Description : hPD-L1(NM-HU-00
    • Nomenclature : C57BL/6Smoc-Cd2
    • Strain : Embryo cryopres
    • KI/KO Gene : Cd274
    • Synonyms : B7h1; Pdl1; P
  • hPD-L1/h4-1BB(2)

    hPD-L1/h4-1BB(2)

    • Description : hPD-L1(NM-HU-00
    • Nomenclature : C57BL/6Smoc-Cd2
    • Strain : Embryo cryopres
    • KI/KO Gene : Cd274
    • Synonyms : B7h1; Pdl1; P
  • hPD-L1(BALB/c)

    hPD-L1(BALB/c)

    • Description : The endogenous
    • Nomenclature : BALB/cAnSmoc-Cd
    • Strain : Repository Live
    • KI/KO Gene : Cd274
    • Synonyms : B7h1; Pdl1; P
  • hPD-L1/hTIGIT

    hPD-L1/hTIGIT

    • Description : hPD-L1(NM-HU-00
    • Nomenclature : C57BL/6Smoc-Cd2
    • Strain : Repository Live
    • KI/KO Gene : Cd274
    • Synonyms : B7h1; Pdl1; P
  • hSIGLEC10

    hSIGLEC10

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Sig
    • Strain : Repository Live
    • KI/KO Gene : Siglecg
    • Synonyms : Siglec-G; Sigl
  • hSERPINH1

    hSERPINH1

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Ser
    • Strain : Sperm cryoprese
    • KI/KO Gene : Serpinh1
    • Synonyms : J6; Cbp1; Cbp2;
  • hRSPO1

    hRSPO1

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Rsp
    • Strain : Sperm cryoprese
    • KI/KO Gene : Rspo1
    • Synonyms : Rspondin; R-spo
  • hSOST

    hSOST

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Sos
    • Strain : Repository Live
    • KI/KO Gene : Sost
    • Synonyms : 5430411E23Rik
  • hSOD1

    hSOD1

    • Description : The endogenous
    • Nomenclature : C57BL/6Smoc-Sod
    • Strain : Repository Live
    • KI/KO Gene : Sod1
    • Synonyms : Ipo1; SODC; Ipo