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Humanized Knockins

Shanghai Model Organisms Center, Inc.

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hTREM2(2)

    hTREM2(2)

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tr
    • Strain : Repository Live
    • KI/KO Gene : Trem2
    • Synonyms : TREM-2, Trem2a,
  • hVSIG4

    hVSIG4

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Vs
    • Strain : Repository Live
    • Target : Immune Checkpoi
    • KI/KO Gene : Vsig4
  • hTSLP(M-NSG)

    hTSLP(M-NSG)

    • Description : Model Descripti
    • Nomenclature : M-NSG-Tslptm(hT
    • Strain : Repository Live
    • Target : Immune Checkpoi
    • KI/KO Gene : Tslp
  • pAtp4b-hCLDN18.2-Tg

    pAtp4b-hCLDN18.2-Tg

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Tslp
  • pAlb-hLPA-Tg

    pAlb-hLPA-Tg

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Repository Live
    • Target : Metabolic Targe
    • KI/KO Gene : LPA
  • Rag2/IL2rg-KO/hKDR

    Rag2/IL2rg-KO/hKDR

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Il
    • Strain : Repository Live
    • Target : Metabolic Targe
    • KI/KO Gene : IL2RG
  • R26-LSL-hIL4(M-NSG)

    R26-LSL-hIL4(M-NSG)

    • Description : Model Descripti
    • Nomenclature : NOD-PrkdcscidIl
    • Strain : Developing
    • Target : Metabolic Targe
    • KI/KO Gene : Gt(ROSA)26Sor
  • hTNFSF15(2)

    hTNFSF15(2)

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tn
    • Strain : Developing
    • Target : Metabolic Targe
    • KI/KO Gene : Tnfsf15
  • hVISTA

    hVISTA

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Vs
    • Strain : Embryo cryopres
    • Target : Immune Checkpoi
    • KI/KO Gene : Vsir
  • hVEGFA(2)

    hVEGFA(2)

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Ve
    • Strain : Repository Live
    • Target : Other Targets
    • KI/KO Gene : Vegfa
  • hTTR(2)

    hTTR(2)

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tt
    • Strain : Repository Live
    • Target : Other Targets
    • KI/KO Gene : Ttr
  • hTSLP/hIL17RA

    hTSLP/hIL17RA

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Ts
    • Strain : Embryo cryopres
    • Target : Cytokines
    • KI/KO Gene : TSLP
  • hVWF

    hVWF

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Vw
    • Strain : Developing
    • Target : Cytokines
    • KI/KO Gene : Vwf
  • R26-LSL-hIL15-Flag-IRES-EGFP

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Gt
    • Strain : Repository Live
    • Target : Cytokines
    • KI/KO Gene : Gt(ROSA)26Sor
  • hIL3/hCSF2(M-NSG)

    hIL3/hCSF2(M-NSG)

    • Description : Model Descripti
    • Nomenclature : M-NSG-Il3tm(hIL
    • Strain : Repository Live
    • Target : Cytokines
    • KI/KO Gene : Gt(ROSA)26Sor
  • hIL5/hIL5RA(M-NSG)

    hIL5/hIL5RA(M-NSG)

    • Description : Model Descripti
    • Nomenclature : M-NSG-Il5tm(hIL
    • Strain : Repository Live
    • Target : Cytokines
    • KI/KO Gene : Gt(ROSA)26Sor
  • hLILRB1-hLILRB2-Tg

    hLILRB1-hLILRB2-Tg

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Gt(ROSA)26Sor
  • hMLKL

    hMLKL

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Ml
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Mlkl
  • hMET

    hMET

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Me
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Met
  • hCXCL10

    hCXCL10

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Cx
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Cxcl10
  • hCTLA-4/hCD28(BALB/c)

    hCTLA-4/hCD28(BALB/c)

    • Description : Model Descripti
    • Nomenclature : BALB/cAnSmoc-Ct
    • Strain : Embryo cryopres
    • Target : Tumor Targets
    • KI/KO Gene : CD28
  • hF3

    hF3

    hF3

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-F3
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : F3
  • hFCGR-Tg

    hFCGR-Tg

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : FCGR2A
  • hGPNMB

    hGPNMB

    • Description : Model Descripti
    • Nomenclature : C57BL/6JSmoc-Gp
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Gpnmb
  • hGFRAL(BALB/c)

    hGFRAL(BALB/c)

    • Description : Model Descripti
    • Nomenclature : BALB/cAnSmoc-Gf
    • Strain : Developing
    • Target : Tumor Targets
    • KI/KO Gene : Gfral