Topovale

Mfr.No.	T9088
Description	Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
Alternative Names	Topoval
Molecular Formula	C23H23N3O5
Signaling Pathways	DNA Damage/DNA Repair
Smiles	C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5
Cas Number	500214-53-9
Molecular Weight	421.45
Target	Topoisomerase

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SKU	Supplier No.	Size	Your price
BHB20447076	T9088	1 mg	$88	Add to Cart
BHB20447076	T9088	5 mg	$179	Add to Cart
BHB20447076	T9088	10 mg	$255	Add to Cart
BHB20447076	T9088	25 mg	$460	Add to Cart
BHB20447076	T9088	50 mg	$676	Add to Cart
BHB20447076	T9088	100 mg	$962	Add to Cart