Thiolutin

Mfr.No.	SIH-375
Alternative Names	N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide
Appearance	Yellow powder
Function	RNA polymerase inhibitor
Inchi	InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
Inchikey	MHMRAFONCSQAIA-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C8H8N2O2S2
Pubchem Cid	6870
Research Area	Cell Signaling ; Epigenetics and Nuclear Signaling
Safety Phrases	Classification: Danger. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H300 – Fatal if swallowed H330 – Fatal if inhaled Precautionary Phrases: P260 – Do not breathe dust/fume/gas/mist/vapours/spray P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P405 – Store locked up
Smiles	CC(=O)NC1=C2C(=CSS2)N(C1=O)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	87-11-6
Molecular Weight	228.3
Scientific Background	Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at http://www.HSP27.com.
Solubility	May be dissolved in DMSO (15 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	≥98% (TLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92. 2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165. 3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900163-1	SIH-375-1MG	1 mg	$108		Add to Cart
BHB11900163-2	SIH-375-5MG	5 mg	$438		Add to Cart

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