Spautin-1

Mfr.No.	SIH-404
Alternative Names	6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
Appearance	White to beige powder.
Function	Autophagy inhibitor
Inchi	InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
Inchikey	AWIVHRPYFSSVOG-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C15H11F2N3
Pubchem Cid	51037431
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H318- Causes serious eye damage. Precautionary statements: P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Smiles	c1cc(ccc1CNc2c3cc(ccc3ncn2)F)F
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	1262888-28-7
Molecular Weight	271.26
Scientific Background	Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.
Solubility	Soluble in DMSO (15 mg/ml).
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Liu J., et al. (2011) Cell. 147(1): 223-34.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900192-1	SIH-404-5MG	5 mg	$92		Add to Cart
BHB11900192-2	SIH-404-25MG	25 mg	$376		Add to Cart

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