SB431542

Mfr.No.	SIH-511
Alternative Names	SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
Appearance	Yellow solid
Function	ALK4,5 and 7 kinase inhibitor
Inchi	InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
Inchikey	FHYUGAJXYORMHI-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H16N4O3
Pubchem Cid	4521392
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	301836-41-9
Molecular Weight	384.4
Scientific Background	SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor, activin receptor-like kinases. It has been shown to inhibit ALK4, 5, and 7.
Solubility	Soluble to 10 mM in ethanol and to 100 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Laping N.J., et al. (2002) Mol. Pharm. 62(1): 58–64.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900294-1	SIH-511-5MG	5 mg	$134		Add to Cart
BHB11900294-2	SIH-511-25MG	25 mg	$534		Add to Cart

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