S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine

Mfr.No.	T83898
Description	S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 uM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 uM, it significantly lowers the expression of alpha-tubulin, betaIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T). Additionally, when used at 30 uM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.
Molecular Formula	C9H18N2O3S3
Signaling Pathways	Others
Smiles	O=C(O)(CH)(N)CSC(NCCCCS(C)=O)=S
Cas Number	364083-21-6
Molecular Weight	298.45
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20445509	T83898	5 mg	$550		Add to Cart