Rolapitant

Mfr.No.	T3716
Description	Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
Alternative Names	SCH619734
Molecular Formula	C25H26F6N2O2
Signaling Pathways	Neuroscience, GPCR/G Protein
Smiles	C(O(CH)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(C)2(CC(C)3(CN2)NC(=O)CC3)C4=CC=CC=C4
Cas Number	552292-08-7
Molecular Weight	500.48
Target	Neurokinin receptor

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SKU	Supplier No.	Size	Your price
BHB20426352	T3716	1 mL	$93	Add to Cart
BHB20426352	T3716	1 mg	$43	Add to Cart
BHB20426352	T3716	2 mg	$60	Add to Cart
BHB20426352	T3716	5 mg	$85	Add to Cart
BHB20426352	T3716	10 mg	$126	Add to Cart
BHB20426352	T3716	25 mg	$198	Add to Cart
BHB20426352	T3716	50 mg	$328	Add to Cart
BHB20426352	T3716	100 mg	$490	Add to Cart
BHB20426352	T3716	500 mg	$1090	Add to Cart