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Home / Biochemicals / Small Molecules

Rivanicline hemioxalate

SKU : BHB20405941

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Mfr.No.	T12738
Description	Rivanicline hemioxalate, also known as RJR-2403 hemioxalate or (E)-Metanicotine hemioxalate, is a chemical compound acting as a neuronal nicotinic receptor agonist with pronounced selectivity for the alpha4beta2 receptor subtype, showing over 1,000-fold greater selectivity for this subtype (Ki=26 nM) compared to alpha7 receptors (Ki=3.6 uM). Its in vitro studies demonstrate no significant activation of nAChRs in PC12 cells, muscle type nAChRs, or muscarinic receptors at concentrations up to 1 mM. Furthermore, Rivanicline displayed less than one-tenth the potency of nicotine in inducing ileum contraction, with substantially lower efficacy, and failed to antagonize nicotine-induced stimulation of muscle or ganglionic nAChR functions, with an IC50 value greater than 1 mM. Chronic exposure to Rivanicline at 10 microM led to up-regulation of high-affinity nAChRs in M10 cells, mimicking effects observed with nicotine. In vivo studies revealed that Rivanicline significantly reversed scopolamine-induced amnesia and improved working and reference memory in a rat model, while being 15 to 30 times less potent than nicotine in affecting body temperature, respiration, and other physiological responses. Metanicitone s potency was approximately five times lower than nicotine in tail-flick tests following subcutaneous administration, yet slightly more potent upon central administration.
Alternative Names	RJR-2403 hemioxalate
Molecular Formula	C12H16N2O4
Signaling Pathways	Others
Smiles	CNCC/C=C/C1=CC=CN=C1.OC(C(O)=O)=O.(0.5)
Molecular Weight	207.23
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20405941	T12738	500 mg	$1774		Add to Cart

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