Pifithrin mu

Mfr.No.	SIH-325
Alternative Names	2-Phenylethynesulfonamide, PFTµ
Appearance	White to off-white solid
Function	Hsp70 Inhibitor
Inchi	InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
Inchikey	ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C8H7NO2S
Pubchem Cid	327653
Published Application	In vitro inhibition ; HSP70 inhibitor assay
Published Species Reactivity	Human ; Mouse
Pubmed Id	25026551 ; 23050124
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338
Smiles	C1=CC=C(C=C1)C#CS(=O)(=O)N
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	64984-31-2
Molecular Weight	181.2
Scientific Background	Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Solubility	Soluble in ethanol (110 mM) and in DMSO (110 mM)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900114-2	SIH-325-50MG	50 mg	$167		Add to Cart
BHB11900114-1	SIH-325-10MG	10 mg	$45		Add to Cart