PF-06843195 is a selective PI3Kalpha inhibitor, demonstrating potent activity with an IC50 of 18 nM in Rat1 fibroblasts and Kis for PI3Kalpha and PI3Kdelta less than 0.018 nM and 0.28 nM, respectively, in biochemical kinase assays. It effectively suppresses the PI3K/mTOR signaling pathway and exhibits durable antitumor efficacy(1).