ORY-1001 free base

Mfr.No.	T28269
Description	ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers (EC50 me2H3K4 and FACS CD11b <1nM). ORY-1001 induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM). ORY-1001 does not inhibit non-related histone modifiers.
Alternative Names	ORY-1001
Molecular Formula	C15H22N2
Signaling Pathways	Others
Smiles	N((CH)1(CH)(C1)C2=CC=CC=C2)(CH)3CC(CH)(N)CC3
Cas Number	1431304-21-0
Molecular Weight	230.35
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20418118	T28269	25 mg	$1520	Add to Cart
BHB20418118	T28269	50 mg	$1980	Add to Cart
BHB20418118	T28269	100 mg	$2500	Add to Cart