Potent and selective p38alpha and p38beta degrader (DC50 < 50 nM). Displays no significant degradation of p38gamma, p38delta, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38alpha gene knockout in BBL358 cells. Active in vivo.