Lestaurtinib

Mfr.No.	SIH-460
Alternative Names	KT5555, CEP-701, (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
Appearance	White powder
Function	FLT3, TrkA kinase inhibitor
Inchi	InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
Inchikey	UIARLYUEJFELEN-LROUJFHJSA-N
Mode Of Action	Inhibitor
Molecular Formula	C26H21N3O4
Pubchem Cid	126565
Sd File	C26H21N3O4 APtclcactv07301413002D 0 0.00000 0.00000 54 61 0 0 1 0 0 0 0 0999 V2000 4.2165 0.9222 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.5826 -0.4438 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.5826 1.2882 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.9577 1.8881 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 2.3846 0.1634 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.5225 -1.9127 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3246 2.9407 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2829 -2.9758 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1255 1.9477 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3803 -3.4826 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4941 -2.9475 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2066 3.4826 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1131 2.9828 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4711 -0.2434 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4754 -0.0437 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3084 -2.0176 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9875 -1.1956 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0956 0.0922 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4084 -0.0099 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.8259 -2.1296 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4891 -0.8312 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6620 0.3444 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.6641 -0.6777 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6518 -0.4598 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1310 -1.3619 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1258 1.1293 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7715 -1.7076 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1241 0.4382 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0894 -1.3538 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4366 -1.4269 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3609 1.9061 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2873 -1.9406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2312 1.4263 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6943 2.8707 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5826 -0.4438 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0826 0.4222 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7377 2.7091 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5345 0.9428 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9137 1.7119 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1367 -2.6661 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3250 -2.4950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0742 0.1167 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6358 -0.6426 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8765 -0.2042 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.8178 -0.7574 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0251 -0.6741 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9955 -1.5861 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7782 3.2338 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8173 -3.2902 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6649 1.6421 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3705 -4.1026 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9500 -3.2448 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1920 4.1025 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6451 3.3013 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 3 4 1 0 0 0 0 2 35 1 0 0 0 0 35 36 2 0 0 0 0 1 34 1 0 0 0 0 4 34 1 0 0 0 0 1 5 1 0 0 0 0 28 36 1 0 0 0 0 29 35 1 0 0 0 0 24 25 1 0 0 0 0 25 29 2 0 0 0 0 2 30 1 0 0 0 0 3 31 1 0 0 0 0 30 32 2 0 0 0 0 31 33 2 0 0 0 0 5 26 1 0 0 0 0 23 24 1 0 0 0 0 20 27 1 0 0 0 0 20 25 1 0 0 0 0 19 23 2 0 0 0 0 5 21 1 6 0 0 0 1 15 1 1 0 0 0 5 14 1 0 0 0 0 6 30 1 0 0 0 0 7 31 1 0 0 0 0 8 32 1 0 0 0 0 9 33 1 0 0 0 0 14 22 1 0 0 0 0 10 11 1 0 0 0 0 6 11 2 0 0 0 0 7 12 2 0 0 0 0 12 13 1 0 0 0 0 4 26 1 0 0 0 0 3 36 1 0 0 0 0 29 32 1 0 0 0 0 28 33 1 0 0 0 0 24 28 2 0 0 0 0 8 10 2 0 0 0 0 23 27 1 0 0 0 0 9 13 2 0 0 0 0 4 37 1 6 0 0 0 26 38 1 0 0 0 0 26 39 1 0 0 0 0 16 27 1 0 0 0 0 20 40 1 0 0 0 0 20 41 1 0 0 0 0 17 21 1 0 0 0 0 15 42 1 0 0 0 0 15 43 1 0 0 0 0 15 44 1 0 0 0 0 14 45 1 0 0 0 0 14 46 1 0 0 0 0 6 47 1 0 0 0 0 7 48 1 0 0 0 0 8 49 1 0 0 0 0 9 50 1 0 0 0 0 18 22 1 0 0 0 0 10 51 1 0 0 0 0 11 52 1 0 0 0 0 12 53 1 0 0 0 0 13 54 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	[C@@]67([N]2C1=C5C(=C4C(=C1C3=C2C=CC=C3)CNC4=O)C8=C([N]5[C@H](O6)C[C@]7(O)CO)C=CC=C8)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	111358-88-4
Molecular Weight	439.5
Scientific Background	Lestaurtinib is potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor. Specifically, it prevents STAT5 phosphorylation. Lestaurtinib exhibits antiproliferative activity in vitro.
Solubility	Soluble to 100 mM in DMSO and to 25 mM in ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Weisel K.C., et al. (2007) Ann. NY Acad. Sci. 1106: 190–196. 2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900244-1	SIH-460-1MG	1 mg	$168		Add to Cart
BHB11900244-2	SIH-460-5MG	5 mg	$534		Add to Cart

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Lestaurtinib

Rate it now..!!