LDN-57444

Mfr.No.	SIH-332
Alternative Names	3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444
Appearance	Yellow Powder
Function	DUB inhibitor
Inchi	InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
Inchikey	OPQRFPHLZZPCCH-PGMHBOJBSA-N
Mode Of Action	Inhibitor
Molecular Formula	C17H11Cl3N2O3
Pubchem Cid	16760696
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed H317 – May cause an allergic skin reaction Precautionary Statements: P280 – Wear protective gloves.
Smiles	CC(=O)O/N=C1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	668467-91-2
Molecular Weight	397.6
Scientific Background	Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.
Solubility	Soluble in 20 mg/ml DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Liu Y., et al. (2003) Chem. Biol. 10: 837. 2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109. 3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900121-1	SIH-332-10MG	10 mg	$114		Add to Cart
BHB11900121-2	SIH-332-50MG	50 mg	$461		Add to Cart