Kigamicin C

Mfr.No.	T37844
Description	Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth of several pancreatic cancer cell lines in nude mice. It blocks the activation of Akt induced in PANC-1 cells placed in nutrient-deprived media. Kigamicin can also induce necrosis in human myeloma cells, but not normal lymphocytes, maintained in nutrient-rich media (CC50 = 100 nM).
Molecular Formula	C41H47NO16
Signaling Pathways	Others
Smiles	(H)(C)12Cc3cc4C(C)5(C)OCCN5C(=O)c4c(O)c3-c3c(O)c4c(oc5(CH)(O)(CH)(C(CH)(O)c5c4=O)O(CH)4CC(CH)(O(CH)5C(CH)(OC)(CH)(O)(CH)(C)O5)(CH)(C)O4)c(OCO1)c23
Cas Number	680571-51-1
Molecular Weight	809.818
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20426906	T37844	500 ?g	$758		Add to Cart