K252A

Mfr.No.	SIH-455
Alternative Names	(9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
Appearance	White solid
Function	Kinase inhibitor
Inchi	InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
Inchikey	KOZFSFOOLUUIGY-CYBHFKQVSA-N
Mode Of Action	Inhibitor
Molecular Formula	C27H21N3O5
Pubchem Cid	11612445
Sd File	C27H21N3O5 APtclcactv07301412542D 0 0.00000 0.00000 56 63 0 0 1 0 0 0 0 0999 V2000 6.2279 -0.4438 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2279 1.2882 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.6031 1.8881 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 4.8619 0.9222 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.1678 -1.9127 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1395 -2.9475 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0256 -3.4826 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9282 -2.9758 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7708 1.9477 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.7584 2.9828 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8519 3.4826 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9699 2.9407 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3938 -0.0623 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1207 -0.0437 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.9537 -2.0176 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7009 -1.0833 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0537 -0.0099 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0119 -1.2379 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.4712 -2.1296 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1345 -0.8312 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.1164 -0.2434 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3074 0.3444 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.3094 -0.6777 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2972 -0.4598 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7764 -1.3619 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7711 1.1293 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.4168 -1.7076 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.0063 1.9061 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8766 1.4263 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.7694 0.4382 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7348 -1.3538 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.9327 -1.9406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0820 -1.4269 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0299 0.1634 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3397 2.8707 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2279 -0.4438 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7279 0.4222 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3831 2.7091 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6408 -1.5861 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5954 -3.2448 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0158 -4.1026 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4626 -3.2902 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7820 -2.6661 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9704 -2.4950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3103 1.6421 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.2904 3.3013 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.8373 4.1025 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4236 3.2338 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1798 0.9428 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5591 1.7119 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6460 -0.6287 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1726 -0.3145 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1417 0.5041 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7196 0.1167 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2812 -0.6426 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5218 -0.2042 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 36 1 0 0 0 0 1 33 1 0 0 0 0 1 4 1 0 0 0 0 36 37 1 0 0 0 0 31 36 2 0 0 0 0 2 37 1 0 0 0 0 30 37 2 0 0 0 0 2 28 1 0 0 0 0 2 3 1 0 0 0 0 28 29 1 0 0 0 0 12 28 2 0 0 0 0 29 30 1 0 0 0 0 9 29 2 0 0 0 0 24 30 1 0 0 0 0 24 25 2 0 0 0 0 23 24 1 0 0 0 0 25 31 1 0 0 0 0 19 25 1 0 0 0 0 31 32 1 0 0 0 0 32 33 2 0 0 0 0 8 32 1 0 0 0 0 5 33 1 0 0 0 0 5 6 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 19 27 1 0 0 0 0 23 27 1 0 0 0 0 17 23 2 0 0 0 0 9 10 1 0 0 0 0 10 11 2 0 0 0 0 11 12 1 0 0 0 0 3 38 1 6 0 0 0 3 35 1 0 0 0 0 3 26 1 0 0 0 0 4 35 1 0 0 0 0 4 34 1 0 0 0 0 4 14 1 1 0 0 0 26 34 1 0 0 0 0 20 34 1 0 0 0 0 21 34 1 0 0 0 0 18 21 2 0 0 0 0 21 22 1 0 0 0 0 13 22 1 0 0 0 0 5 39 1 0 0 0 0 6 40 1 0 0 0 0 7 41 1 0 0 0 0 8 42 1 0 0 0 0 19 43 1 0 0 0 0 19 44 1 0 0 0 0 15 27 1 0 0 0 0 9 45 1 0 0 0 0 10 46 1 0 0 0 0 11 47 1 0 0 0 0 12 48 1 0 0 0 0 26 49 1 0 0 0 0 26 50 1 0 0 0 0 16 20 1 0 0 0 0 13 51 1 0 0 0 0 13 52 1 0 0 0 0 13 53 1 0 0 0 0 14 54 1 0 0 0 0 14 55 1 0 0 0 0 14 56 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	[N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[C@@H]5O[C@]4(C(C5)(O)C(=O)OC)C)C(NC6)=O)C8=C7C=CC=C8
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	99533-80-9
Molecular Weight	467.5
Scientific Background	K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent autophosphorylation and activation of downstream effectors.
Solubility	Soluble to 25 mM in DMSO
Source	Nonomuraea longicatena
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.0001
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Morotti A., Mila S., Accorner, P., Tagliabue E., & Ponzetto C. (2002) Oncogene. 21(32): 4885–4893. 2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429. 3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900239-2	SIH-455-1MG	1 mg	$234		Add to Cart
BHB11900239-1	SIH-455-100UG	100 ug	$66		Add to Cart

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of K252A

Rate it now..!!