HNMPA-(AM)3 inhibits activation of ERK phosphorylation and stimulation of ecdysteroid production by prothyrotropin (PTTH). Furthermore, HNMPA-(AM)3 had inhibitory effects on ecdysteroid production (IC50=14.2 uM) and insulin receptor activity (IC50=14.2 uM and 200 uM, in mosquitoes and mammals, respectively).