GYKI 52466 HCl

Mfr.No.	T70063
Description	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 uM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 uM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 uM).2 GYKI 52466 (10 uM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion.
Molecular Formula	C17H16ClN3O2
Signaling Pathways	Others
Smiles	Cl.CC1=NN=C(c2ccc(N)cc2)c2cc3OCOc3cc2C1
Cas Number	192065-56-8
Molecular Weight	329.784
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20437335	T70063	10 mg	$330		Add to Cart