GF109203X

Mfr.No.	SIH-447
Alternative Names	2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide, 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I
Appearance	Red solid
Function	PKC kinase inhibitor
Inchi	InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
Inchikey	QMGUOJYZJKLOLH-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C25H24N4O2
Pubchem Cid	2396
Sd File	C25H24N4O2 APtclcactv07301412522D 0 0.00000 0.00000 55 59 0 0 0 0 0 0 0 0999 V2000 5.2619 0.5908 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7459 1.0702 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 1.5908 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.4092 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1041 3.2828 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2741 1.6607 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 1.0908 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.0908 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0990 3.3838 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6840 2.5728 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9889 -1.1644 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3211 -1.9087 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6318 -2.8593 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2746 -4.5541 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9854 -3.3973 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8012 4.5541 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8786 0.1683 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6783 1.3955 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7485 2.0643 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4025 3.1578 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.7523 4.2398 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.9889 2.3461 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9405 2.6534 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4025 3.1561 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9423 3.6534 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9639 -3.6036 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 4.9917 3.9641 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 1.0908 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 0.0908 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.6942 2.3706 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.2792 1.5596 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6783 -0.2139 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.6900 0.7589 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.8819 0.5908 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2431 0.7075 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 2.2108 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -1.0292 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7414 3.7856 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3715 -1.6523 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5359 -0.8724 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6368 1.1578 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 1.4008 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -0.2192 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3531 3.9494 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.3008 2.6355 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9385 -1.4208 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7742 -2.2008 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0143 -3.3472 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1787 -2.5672 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6852 -4.7467 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4672 -5.1434 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8639 -4.3615 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1133 -2.7907 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3787 -3.2695 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8575 -4.0040 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 20 24 2 0 0 0 0 21 25 2 0 0 0 0 29 32 1 0 0 0 0 1 32 1 0 0 0 0 11 32 1 0 0 0 0 24 27 1 0 0 0 0 25 27 1 0 0 0 0 31 33 1 0 0 0 0 2 33 1 0 0 0 0 13 26 1 0 0 0 0 14 26 1 0 0 0 0 15 26 1 0 0 0 0 22 23 2 0 0 0 0 18 22 1 0 0 0 0 22 24 1 0 0 0 0 19 23 1 0 0 0 0 23 25 1 0 0 0 0 18 28 1 0 0 0 0 1 18 2 0 0 0 0 19 30 1 0 0 0 0 2 19 2 0 0 0 0 28 29 2 0 0 0 0 3 28 1 0 0 0 0 4 29 1 0 0 0 0 30 31 1 0 0 0 0 5 30 2 0 0 0 0 6 31 2 0 0 0 0 3 7 2 0 0 0 0 4 8 2 0 0 0 0 5 9 1 0 0 0 0 11 12 1 0 0 0 0 6 10 1 0 0 0 0 7 8 1 0 0 0 0 9 10 2 0 0 0 0 12 13 1 0 0 0 0 16 27 1 0 0 0 0 17 33 1 0 0 0 0 1 34 1 0 0 0 0 2 35 1 0 0 0 0 3 36 1 0 0 0 0 4 37 1 0 0 0 0 5 38 1 0 0 0 0 11 39 1 0 0 0 0 11 40 1 0 0 0 0 6 41 1 0 0 0 0 7 42 1 0 0 0 0 8 43 1 0 0 0 0 9 44 1 0 0 0 0 10 45 1 0 0 0 0 12 46 1 0 0 0 0 12 47 1 0 0 0 0 13 48 1 0 0 0 0 13 49 1 0 0 0 0 14 50 1 0 0 0 0 14 51 1 0 0 0 0 14 52 1 0 0 0 0 15 53 1 0 0 0 0 15 54 1 0 0 0 0 15 55 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Acute toxicity, Oral (Category 4), H302 Carcinogenicity (Category 2), H351 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H351 Suspected of causing cancer. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P301 + P312 IF SWALLOWED: C all a POISON CENTER or doctor/ physician if you feel unwell. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
Smiles	C4=C(C3=C(C1=C[NH]C2=CC=CC=C12)C(=O)NC3=O)C5=C([N]4CCCN(C)C)C=CC=C5
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	133052-90-1
Molecular Weight	412.5
Scientific Background	GF109203X is a very potent inhibitor of protein kinase C; it is selective for the α and β1 isoforms; this could lead to an increase in autophagy. GF109203X is also an inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-inflammatory effects. It has also been seen to inhibit telomerase activity and necrosis.
Solubility	Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	≥98% (TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Toullec D., et al. (1991) J. Biol. Chem. 266(24): 15771–15781. 2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002. 3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180. 4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900231-1	SIH-447-1MG	1 mg	$85		Add to Cart
BHB11900231-2	SIH-447-10MG	10 mg	$190		Add to Cart

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