Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . (1) It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 ug/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. (2) It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 ug/ml).(3)