Entrectinib

Mfr.No.	T3678
Description	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M resistance mutations, and inhibits ALK?dependent signaling. It has been shown to inhibit the growth of a non-small cell lung Y cell line bearing an EML4-ALK rearrangement. In mice bearing various ROS1, Trk, or ALK-driven xenografts, Entrectinib has been shown to induce tumor regression.
Alternative Names	RXDX-101
Molecular Formula	C31H34F2N6O2
Signaling Pathways	Immunology/Inflammation, Angiogenesis, Tyrosine Kinase/Adaptors, Autophagy
Smiles	N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5
Cas Number	1108743-60-7
Molecular Weight	560.64
Target	ROS, ROS Kinase, Autophagy, ALK, Trk receptor

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SKU	Supplier No.	Size	Your price
BHB20426022	T3678	1 mL	$63	Add to Cart
BHB20426022	T3678	2 mg	$35	Add to Cart
BHB20426022	T3678	5 mg	$54	Add to Cart
BHB20426022	T3678	10 mg	$81	Add to Cart
BHB20426022	T3678	25 mg	$113	Add to Cart
BHB20426022	T3678	50 mg	$171	Add to Cart
BHB20426022	T3678	100 mg	$297	Add to Cart
BHB20426022	T3678	500 mg	$728	Add to Cart