D-erythro/L-threo Lysosphingomyelin (d18:1)

Mfr.No.	T37187
Description	Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin.
Molecular Formula	C23H49N2O5P
Signaling Pathways	Others
Smiles	CCCCCCCCCCCCCC=CC(O)C(N)COP((O-))(=O)OCC(N+)(C)(C)C \|w:14.14\|
Cas Number	82970-80-7
Molecular Weight	464.628
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20426376	T37187	5 mg	$245	Add to Cart
BHB20426376	T37187	10 mg	$411	Add to Cart
BHB20426376	T37187	50 mg	$1965	Add to Cart