AG126

Mfr.No.	T4092
Description	AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 uM. It blocks the production of TNF-alpha in vitro2 and in vivo, attenuating signaling through NF-kappaB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 uM) and platelet-derived GFRK (IC50 > 100 uM).
Alternative Names	AG 126
Molecular Formula	C10H5N3O3
Signaling Pathways	Neuroscience, Immunology/Inflammation, MAPK
Smiles	N(=O)(=O)C1=C(O)C=C(C=C(CN)CN)C=C1
Cas Number	118409-62-4
Molecular Weight	215.16
Target	COX, ERK

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SKU	Supplier No.	Size	Your price
BHB20428765	T4092	1 mL	$71	Add to Cart
BHB20428765	T4092	1 mg	$30	Add to Cart
BHB20428765	T4092	2 mg	$43	Add to Cart
BHB20428765	T4092	5 mg	$67	Add to Cart
BHB20428765	T4092	10 mg	$117	Add to Cart
BHB20428765	T4092	25 mg	$233	Add to Cart
BHB20428765	T4092	50 mg	$346	Add to Cart
BHB20428765	T4092	100 mg	$513	Add to Cart