Adenosine-5'-O-(3-thiotriphosphate) (ATPgammaS), an agonist of the purinergic P2Y11 receptor, prompts inositol phosphate accumulation in CHO-K1 cells harboring the human or canine P2Y11 receptor with EC50 values of 1.2 and 19.3 uM, respectively. At a concentration of 10 uM, ATPgammaS mitigates Junin virus-induced mRNA boosts pertaining to bone morphogenetic protein 6 (BMP6) and diminishes particle forming units (PFUs) in infected primary rat osteoblasts. Furthermore, when applied at 25 uM, it triggers insulin secretion in MIN6 pancreatic beta-cells.