(Z)-Lanoconazole is the Z configuration of Lanoconazole which used for dermatophytosis and onychomycosis investigation. Lanoconazole inhibits sterol 14-alpha demethylase and blocks fungal membrane ergosterol biosynthesis that interferes with ergosterol biosynthesis. Lanoconazole is a potent and orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo (1) (2).