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Home / Primary Antibodies / Monoclonal Antibodies

Recombinant VEGI Antibody / TL1A / TNFSF15

SKU : BHA17114809

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NSJ Bioreagents

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Mfr.No.	V3785, V3785-20UG, V3785-100UG
Clonality	Monoclonal
Description	Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is a protein that in humans is encoded by the TNFSF15 gene. TL1A/VEGI is an anti-angiogenic protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. It is the sole known ligand for death receptor 3, and it can also be recognized by decoy receptor 3.<p>TL1A/VEGI is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF-alpha and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-kB and MAPK signalling pathways, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. (Wiki)
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Rabbit
Immunogen Region	A full length human recombinant protein was used as the immunogen for this recombinant VEGI antibody.
Isotype	IgG,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	Yes
Subcellular Location	Cytoplasmic, cell surface, secreted

Antigen	TNFSF15
Uniprot	O95150
Clone No	TLRM1-2R

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein A affinity chromatography
Storage	Store the recombinant VEGI antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml,Prediluted IHC only format : incubate for 30 min at RT (1)

Product Manual	Data Sheet

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