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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human Regulator of G-protein signaling 2 (RGS2)

SKU : BHP10504142

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP019651HU
Description	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving th into their inactive GDP-bound form. May play a role in leukogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Alternative Names	Cell growth-inhibiting gene 31 protein,G0/G1 switch regulatory protein 8, Cell growth-inhibiting gene 31 protein ; G0/G1 switch regulatory protein 8
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving th into their inactive GDP-bound form. May play a role in leukogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-211aa
Mol Weight	40.4kDa
Nature	Recombinant
Protein Description	Full Length

Subcellular Location	Isoform 1: Cell membrane, Cytoplasm, Nucleus, nucleolus, SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Cytoplasm, Nucleus, nucleolus, SUBCELLULAR LOCATION: Isoform 3: Cell membrane, Cytoplasm, Nucleus, nucleolus, SUBCELLULAR LOCATION: Isoform 4: Cell membrane, Mitochondrion
Uniprot	P41220, P41220
Database Links	HGNC:9998 OMIM:600861 KEGG:hsa:5997 STRING:9606.ENSP00000235382 UniGene:Hs.78944
Function	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form
Pathway	cGMP-PKG signaling pathway
Research Area	Signal Transduction
Tissue Specificity	Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Weight	40.4 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504142	CSB-EP019651HU	20ug	$224		Add to Cart
BHP10504142	CSB-EP019651HU	100ug	$419		Add to Cart
BHP10504142	CSB-EP019651HU	1mg	$1812		Add to Cart

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