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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 (MICAL2), partial

SKU : BHP10502392

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP013808HU
Alternative Names	Molecule interacting with CasL protein 2 ,MICAL-2, Molecule interacting with CasL protein 2 ; MICAL-2
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Protein-methionine sulfoxide oxidase MICAL2; EC= 1.14.13.-; Alternative name(s): Molecule interacting with CasL protein 2; Short name= MICAL-2
Expression Region	1-495aa
Mol Weight	58.5kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Nucleus
Uniprot	O94851, O94851
Database Links	HGNC:24693 OMIM:608881 KEGG:hsa:9645 STRING:9606.ENSP00000256194 UniGene:Hs.501928
Function	Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum
Protein Families	Mical family
Research Area	Cell Biology
Weight	58.48kDa
Antigen	MICAL2

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502392	CSB-YP013808HU	20ug	$250		Add to Cart
BHP10502392	CSB-YP013808HU	100ug	$470		Add to Cart
BHP10502392	CSB-YP013808HU	1mg	$2010		Add to Cart

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