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Recombinant Human Macrophage colony-stimulating factor 1 protein (CSF1), partial (Active)

BHP10500068
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Involvement In Disease Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.; DISEASE: Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
Subcellular Location Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed macrophage colony-stimulating factor 1: Secreted, extracellular space
Uniprot P09603, P09603
Database Links

HGNC:2432

OMIM:120420

KEGG:hsa:1435

STRING:9606.ENSP00000327513

UniGene:Hs.173894
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Pathway MAPK signaling pathway; PI3K-Akt signaling pathway; TNF signaling pathway; Ras signaling pathway; Hematopoietic cell lineage; Osteoclast differentiation; Rap1 signaling pathway
Research Area Immunology
Weight 36.8 kDa
Antigen CSF1
Buffer 0. 2µm filtered PBS, pH7.4,lyophilized
Purity >95% as determined by SDS-PAGE and HPLC.
Storage Buffer 0. 2um filtered PBS, pH7.4 ,lyophilized
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10500068 CSB-AP002131HU 10ug $354
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BHP10500068 CSB-AP002131HU 100ug $1672
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BHP10500068 CSB-AP002131HU 500ug $3750
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