Fibronectin (FN) is an extracellular glycoprotein that exists in soluble form in body fluids or in insoluble form in the extracellular matrix. As one of the main cell adhesion molecules, FN plays a key role in many important physiological processes, such as embryogenesis, wound healing, hemostasis and thrombosis. Changes in fibronectin expression, degradation and combination are closely related to a large number of pathological occurrences, including cancer and fibrosis.