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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)

BHP10506272
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Involvement In Disease Lung cancer (LNCR); Inflammatory skin and bowel disease, neonatal, 2 (NISBD2)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Endoplasmic reticulum membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Nucleus membrane, Single-pass type I membrane protein, Endosome, Endosome membrane, Nucleus
Uniprot P00533
Database Links

HGNC:3236

OMIM:131550

KEGG:hsa:1956

STRING:9606.ENSP00000275493

UniGene:Hs.488293
Function Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity).
Pathway Calcium signaling pathway; ErbB signaling pathway; Estrogen signaling pathway; HIF-1 signaling pathway; Jak-STAT signaling pathway; MAPK signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Gap junction; Regulation of actin cytoskeleton; Adherens junction; Ras signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; Rap1 signaling pathway; Endocytosis
Protein Families Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Research Area Cancer
Tissue Specificity Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Purity Greater than 90% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Storage Buffer Tris-based buffer，50% glycerol
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10506272 CSB-MP007479HU 20ug $144
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BHP10506272 CSB-MP007479HU 100ug $362
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BHP10506272 CSB-MP007479HU 1mg $2450
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