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Home / Proteins & Peptide

Recombinant BMP-3B, Human

SKU : BHP11300010

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Mfr.No.	BK0011‐10μg
Description	Bone Morphogenetic Protein-3B (BMP-3B) , also known as Growth/Differentiation Factor 10 (GDF-10), is a cytokine belonging to the Transforming Growth Factor β (TGF-β) superfamily. BMP-3B contains the cystine knot motif shared by other TGF-β family members. BMP-3B was originally identified by PCR based on the BMP-3 sequence, and shares 83% identity with BMP-3. BMP-3B and BMP-2 act as mutual antagonists, as they compete for the availability of signaling protein Smad4. In vivo, BMP-3B is highly expressed in brain, lungs, and bone tissues. The functions of BMP-3B include acting as a dorsaling factor in head development, inhibition of adipogenesis in adipocytes, and induction of bone formation. BMP-3B is down-regulated in lung cancer patient samples, indicating its potential antitumor activity. Recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 111 amino acids each. rhBMP-3B has a molecular mass of 25.1 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Alternative Names	Osteogenin ; BMP-3A ; BMP3B ; BMP3A
Regulatory	RUO
Source	Escherichia coli.
Host	Human
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Nature	Recombinant

Weight	25.1 kDa, observed by non-reducing SDS-PAGE.
Antigen	BMP-3B

Description	Reconstituted in 4mM HCl at 100 μg/mL.
Format	Lyophilized after extensive dialysis against 4mM HCl. Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	> 95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-3B remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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SKU	Supplier No.	Size	Your price	Quantity
BHP11300010	BK0011‐10μg	10μg	$173.16		Add to Cart
BHP11300010	BK0011‐10μg	1mg	$2055.56		Add to Cart
BHP11300010	BK0011‐10μg	50μg	$290		Add to Cart

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