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Home / Primary Antibodies / Recombinant Antibodies

Phospho-RB1 (S807) Recombinant Monoclonal Antibody (CSB-RA019386A807phHU)

SKU : BHA10564560

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA019386A807phHU
Alternative Names	Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Immunogen	A synthesized peptide derived from Human Phospho-RB1 (S807)
Involvement In Disease	Childhood cancer retinoblastoma (RB); Bladder cancer (BLC); Osteogenic sarcoma (OSRC)
Isotype	IgG
Reactivity	Human
Relevance	Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Subcellular Location	Nucleus

Antigen	RB1
Uniprot	P06400
Gene Name	RB1
Database Links	HGNC:9884 OMIM:109800 KEGG:hsa:5925 STRING:9606.ENSP00000267163 UniGene:Hs.408528
Function	Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Pathway	Cell cycle Cellular senescence
Protein Families	Retinoblastoma protein (RB) family
Research Area	Cell Biology
Tissue Specificity	Expressed in the retina.

Form	Liquid
Purification	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Description	IF ; ELISA
Tested Application	ELISA, IF; Recommended dilution: IF:1:20-1:200

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10564560	CSB-RA019386A807phHU	50ul	$210		Add to Cart
BHA10564560	CSB-RA019386A807phHU	100ul	$350		Add to Cart

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