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Home / Primary Antibodies / Monoclonal Antibodies

Phospho-Histone H2AX (S139) Antibody

SKU : BHA10560698

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RA010097A139phHU
Alternative Names	Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Description	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Host	Rabbit
Immunogen	A synthesized peptide
Isotype	IgG
Reactivity	Human
Regulatory	RUO
Relevance	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus, Chromosome

Uniprot	P16104
Gene Name	H2AFX
Database Links	HGNC:4739 OMIM:601772 KEGG:hsa:3014 STRING:9606.ENSP00000364310 UniGene:Hs.477879
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Pathway	Necroptosis
Protein Families	Histone H2A family
Research Area	Epigenetics and Nuclear Signaling

Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Liquid
Format	Liquid
Purification	Affinity-chromatography
Purity	Affinity-chromatography
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA ; IHC

Dilution

WB	1:3000-1:10000

Tested Application

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560698	CSB-RA010097A139phHU	100ul	$350		Add to Cart
BHA10560698	CSB-RA010097A139phHU	50ul	$210		Add to Cart

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