Mouse Anti-Rat GluN2B Monoclonal IgG2b

Mfr.No.	SMC-337, SMC-337D, SMC-337D-A390, SMC-337D-A488, SMC-337D-A594, SMC-337D-APC, SMC-337D-BI, SMC-337D-FITC, SMC-337D-HRP, SMC-337D-PCP, SMC-337D-RPE, SMC-337S
Immunogen Species	Rat
Alternative Names	NMDAR2B Antibody, hNR3 Antibody, MGC142180 Antibody, glutamate receptor subunit epsilon-2 Antibody, NR3 Antibody
Categories	Antibodies
Cellular Localization	Cell Membrane, Cell Junction, Synapse, Postsynaptic Cell Membrane
Certificate Of Analysis	1 ug/ml of SMC-337 was sufficient for detection of NR2B in 10 ug of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat GluN2B/NR2B Monoclonal IgG2b
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B, Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B
Isotype	IgG2b
Launch Date	2010/03/31
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	NR2B
Swissprot	Q00960
Accession Number	NP_036706.1
Gene Id	24410
Target	NR2B
Clone No	S59
Research Area	Ion Channels, Neurotransmitter Receptors, NMDA Receptors, Neurodegeneration, Glutamate Receptors, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	NR2B containing receptors have been implicated in synaptic plasticity, memory formation and pain modulation (1). Studies suggest that the NR2B subunit of glutamate receptors may be potential targets for relieving pain; NR2B may be a probable target for anti-nociceptive drugs, and may also be useful as analgesics (2).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~166kDa. No cross-reactivity against NR2A.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, IHC, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP ; AM
Dilution	WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Zhuo M. (2009) Mol Brain. 2(1): 4 2. Gurwitz D, and Weizman A. (2002) Drug Discovery Today, 7(7): 403-406.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11903108-1	SMC-337D	Unconjugated	100 ug	$337	Add to Cart
BHA11903108-2	SMC-337D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11903108-3	SMC-337D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11903108-4	SMC-337D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11903108-5	SMC-337D-APC	APC	100 ug	$390	Add to Cart
BHA11903108-6	SMC-337D-BI	Biotin	100 ug	$386	Add to Cart
BHA11903108-7	SMC-337D-FITC	FITC	100 ug	$381	Add to Cart
BHA11903108-8	SMC-337D-HRP	HRP	100 ug	$377	Add to Cart
BHA11903108-9	SMC-337D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11903108-10	SMC-337D-RPE	RPE	100 ug	$388	Add to Cart
BHA11903108-11	SMC-337S	Unconjugated	12 ug	$45	Add to Cart

GluN2B (NR2B, NMDA Receptor 2B) Antibody, Clone S59 (SMC-337)